参考文献
[1] YUAN H,Van BLITTERSWIJK C,De GROOT K,et al.A comparison of bone formation in biphasic calcium phosphate (BCP)and hydroxyapatite (HA)implanted in muscle and bone of dogs at different time periods[J].J Biomed Mater Res A,2006,78(1):139-147.
[2] YUAN H,Van BLITTERSWIJK C,De GROOT K,et al.Cross-species comparison of ectopic bone formation in biphasic calcium phosphate (BCP)and hydroxyapatite(HA)scaffolds[J].Tiss Eng,2006,12(6):1607-1615.
[3] BAO C Y,ZHANG Y Z,WANG H L,et al.Stress analysis and optimizing of osteoinductive Ca-P ceramics and Net-Cage-structured titanium alloy in dog segmental femoral defect reparation[J].Key Engin Mater,2006,309:231-234.
[4] TANG Z,TAN Y,NI Y,et al.Comparison of ectopic bone formation process induced by four calcium phosphate ceramics in mice[J].Mater Sci Engin C,2017,70(2):1000-1010.
[5] WANG J,CHEN Y,ZHU X,et al.Effect of phase composition on protein adsorption and osteoinduction of porous calcium phosphate ceramics in mice[J].J Biomed Mater Res Part A,2014,102(12):4234-4243.
[6] YUAN H,YANG Z,LI Y,et al.Osteoinduction by calcium phosphate biomaterials[J].J Mater Sci Mater Med,1998,9(12):723-726.
[7] De GROOT J.Carriers that concentrate native bone morphogenetic protein in vivo[J].TissueEng,1998,4(4):337-341.
[8] FAN H,IKOMA T,TANAKA J,et al.Surface structural biomimetics and the osteoinduction of calcium phosphate biomaterials[J].J Nanosci Nanotechnol,2007,7(3):808-813.
[9] BARRADAS A,YUAN H,van BLITTERSWIJK C,et al.Osteoinductive biomaterials:current knowledge of properties,experimental models and biological mechanisms[J].Eur Cells Mater,2011,21:407-429.
[10] ZHAO C,ZHU X,LIANG K,et al.Osteoinduction of porous titanium:a comparative study between acid-alkali and chemical-thermal treatments[J].J Biomed Mater Res Part B-Applied Biomaterials,2010,95(2):387-396.
[11] YANG Z,YUAN H,ZOU P,et al.Osteogenic responses to extraskeletally implanted synthetic porous calcium phosphate ceramics:an early stage histomorphological study in dogs[J].J Mater Sci Mater Med,1997,8(11):697.
[12] SONG G,HABIBOVIC P,BAO C,et al.The homing of bone marrow MSCs to non-osseous sites for ectopic bone formation induced by osteoinductive calcium phosphate[J].Biomaterials,2013,34(9):2167-2176.
[13] WANG K,WANG M,WANG Q,et al.Computer simulation of proteins adsorption on hydroxyapatite surfaces with calcium phosphate ions[J].J Eur Ceram Soc,2017,37(6):2509-2520.
[14] ZHU X,FAN H,LI D,et al.Protein adsorption and zeta potentials of a biphasic calcium phosphate ceramic under various conditions[J].J Biomed Mater Res Part B-Applied Biomater,2007,82(1):65-73.
[15] ZHU X,ZHANG H,FAN H,et al.Effect of phase composition and microstructure of calcium phosphate ceramic particles on protein adsorption[J].Acta Biomaterialia,2010,6:1536-1541.
[16] LOU Z,ZENG Q,CHU X,et al.First-principles study of the adsorption of lysine on hydroxyapatite (100)surface[J].Applied Surface Science,2012,258(11):4911-4916.
[17] WANG K,ZHOU C,HONG Y,et al.A review of protein adsorption on bioceramics[J].Interface Focus,2012,2(3):259-277.
[18] WANG J,ZHANG H,ZHU X,et al.Dynamic competitive adsorption of bone-related proteins on calcium phosphate ceramic particles with different phase composition and microstructure[J].J Biomed Mater Res Part B:Applied Biomater,2013,101(6):1069-1077.
[19] TANG Z,WANG Z,QING F,et al.Bone morphogenetic protein Smads signaling in mesenchymal stem cells affected by osteoinductive calcium phosphate ceramics[J].J Biomed Mater Res A,2015,103(3):1001-1010.
[20] CHEN X,WANG J,CHEN Y,et al.Roles of calcium phosphate-mediated integrin expression and MAPK signaling pathways in the osteoblastic differentiation of mesenchymal stem cells[J].J Mater Chem B,2016,4(13):2280-2289.
[21] EYCKMANS J,ROBERTS SJ,SCHROOTEN J,et al.A clinically relevant model of osteoinduction:a process requiring calcium phosphate and BMP/Wnt signalling[J].J Cellular Molecular Med,2010,14(6):1845-1856.
[22] BOLANDER J,CHAI Y,GERIS L,et al.Early BMP,Wnt and Ca2+/PKC pathway activation predicts the bone forming capacity of periosteal cells in combination with calcium phosphates[J].Biomaterials, 2016, 86: 106-118.
[23] CHEN Z,WU C,GU W,et al.Osteogenic differentiation of bone marrow MSCs by beta-tricalcium phosphate stimulating macrophages via BMP2 signaling pathway[J].Biomaterials,2014,35(5):1507-1518.
[24] CHEN X,WANG J,WANG J,et al.The positive role of macrophage secretion stimulated by BCP ceramic in the ceramic-induced osteogenic differentiation of pre-osteoblasts via Smad-related signaling pathways[J].Rsc Advances,2016,6(104):102134-102141.
[25] WANG J,LIU D,GUO B,et al.Role of BCP ceramicmediated secretion of signalling molecules by macrophages in migration and osteoblastic differentiation of MSCs[J].Acta Biomaterialia,2017,51:447-460.
[26] CHAI Y,ROBERTS S,DESMET E,et al.Mechanisms of ectopic bone formation by human osteoprogenitor cells on CaP biomaterial carriers[J].Biomaterials, 2012, 33(11):3127-3142.
[27] CHEN Y,WANG J,ZHU X,et al.Enhanced effect of βtricalcium phosphate phase on neovascularization of porous calcium phosphate ceramics:in vitro and in vivo evidence[J].Acta Biomaterialia,2015,11:435-448.
[28] MEDICI D,OLSEN B.The role of endothelial-mesenchymal transition in heterotopic ossification[J].J Bone Mineral Res,2012,27(8):1619-1622.
[29] TANG Z,LI X,TAN Y,et al.The material and biological characteristics of osteoinductive calcium phosphate ceramics[J].Regen Biomater,2018,5(1):43-59.
[30] YUAN B,CHENG Q,ZHAO R,et al.Comparison of osteointegration property between PEKK and PEEK:Effects of surface structure and chemistry[J].Biomaterials,2018,170(1):116-126.
[31] CHEN H,WANG C,YANG X,et al.Construction of surface HA/TiO2 coating on porous titanium scaffolds and its preliminary biological evaluation[J].Mater Sci Eng C,2017,70(2):1047-1056.
[32] YUAN B,CHEN Y,LIN H,et al.Processing and properties of bioactive surface-porous PEKK[J].ACS Biomater Eng,2016,2(6):977-986.
[33] FUJIBAYASHI S,NEO M,KIM H,et al.Osteoinduction of porous bioactive titanium metal[J].Biomaterials,2004,25(3):443-450.
[34] LI Z,YUAN T,GUO L,et al.An in vitro study of collagen hydrogel to induce the chondrogenic differentiation of mesenchymal stem cells[J].J Biomed Mater Res A,2012,100(10):2717-2725.
[35] ZHANG L,LI K,XIAO W,et al.Preparation of collagenchondroitin sulfate-hyaluronic acid hybrid hydrogel scaffolds and cell compatibility in vitro[J].Carbohyd Polym,2011,84(1):118-125.
[36] ZHENG L,SUN J,CHEN X,et al.In vivo cartilage engineering with collagen hydrogel and allogenous chondrocytes after diffusion chamber implantation in immunocompetent host[J].Tissue Eng Part A,2009,15(8):2145-2153.
[37] LIU J,LIN H,LI X,et al.Chondrocytes behaviors within type I collagen microspheres and bulk hydrogels:an in vitro study[J].Rsc Adv,2015,5(67):54446-54453.
[38] DUAN H,GE W,ZHANG A,et al.Transcriptome analyses reveal molecular mechanisms underlying functional recovery after spinal cord injury[J].Proc Nat Acad Sci USA,2015,112(43):13360.
[39] ZHANG S,EVE Y,DUAN H,et al.NT3-chitosan elicits robust endogenous neurogenesis to enable functional recovery after spinal cord injury[J].Proc Nat Acad Sci USA,2015,112(43):13354-13359.
[40] RAO J,ZHAO C,ZHANG A,et al.NT3-chitosan enables de novo regeneration and functional recovery in monkeys after spinal cord injury[J].Proc Nat Acad Sci USA,2018,115(2):E5595-5604.
[41] HIDEKI A,MASATAKA O.Effect of adracin-adsorbing HAP-sol on Ca-9 cell growth[J].Reports Institute Meal Dental Eng,1993,27:39.
[42] CAO X,QI Z,DAI H.Cytotoxinic mechanism of hydroxyapatite nanoparticles on human hepatoma cell lines[J].J Wuhan Univ Technol-Mater Sci,2003,18:66-68.
[43] ZHANG C,NI D,LIU Y,et al.Magnesium silicide nanoparticles as a deoxygenation agent for cancer starvation therapy[J].Nat Nanotechnol,2017,12:378-386.
[44] WANG X,LV F,LI T,et al.Electrospun micropatterned nanocomposites incorporated with Cu2S nanoflowers for skin tumor therapy and wound healing[J].ACS Nano,2017,11(11):11337-11349.
[45] HAN Y,LI S,CAO X,et al.Different inhibitory effect and mechanism of hydroxyapatite nanoparticles on normal cells and cancer cells in vitro and in vivo[J].Sci Rep,2015,4:7134.
[46] CHEN X,DENG C,TANG S,et al.Mitochondria-dependent apoptosis induced by nanoscale hydroxyapatite in human gastric cancer SGC-7901 cells[J].Biol Pharm Bulletin,2007,30(1):128.
[47] YUAN Y,LIU C,QIAN J,et al.Size-mediated cytotoxicity and apoptosis of hydroxyapatite nanoparticles in human hepatoma HepG2 cells[J].Biomaterials,2010,31(4):730-740.
[48] ZHAO R,XIE P,ZHANG K,et al.Selective effect of hydroxyapatite nanoparticles on osteoporotic and healthy bone formation correlates with intracellular calcium homeostasis regulation[J].Acta Biomater,2017,59:338-350.
[49] LI X,SONG T,CHEN X,et al.Osteoinductivity of porous biphasic calcium phosphate ceramics spheres with nanocrystalline and their efficacy in guiding bone regeneration[J].ACS Appl Mater Interfaces,2019,11(4):3722-3736.
[50] ZHANG K,ZHOU Y,XIAO C,et al.Application of hydroxyapatite nanoparticles in tumor-associated bone segmental defect[J].Sci Adv,2019,5(8):eaax6946.